Engineered Nanoparticles for Cancer Imaging and Therapy
with Emily Day, Ph.D.
Postdoctoral Fellow, International Institute for Nanotechnology
NIH Postdoctoral Fellow
January 24, 2013
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abstract: Knowledge of cancer biology is rapidly increasing, but similar improvements in clinical treatment and patient outcome are not being realized. This discrepancy emphasizes the need for innovative technological platforms that enable tumor-specific therapy. Emily Day’s research focuses on developing engineered nanoparticles with tailored structure and surface chemistry to achieve unique properties that transform imaging and therapy of cancer. This presentation will describe three engineered nanoparticles and demonstrate their potential in biomedicine using cancer as a model system. The talk will show how the core structure and surface layer of these nanoparticles can be modified to enable them to act as contrast agents, photothermal therapeutics, or gene regulatory entities. These materials have been evaluated both in vitro and in vivo against breast and brain cancers and have greatly reduced tumor growth resulting in improved survival, supporting the continued development and application of these nanoparticles for management of cancer and other diseases.
biosketch: Emily Day received her B.S. in physics with a minor in mathematics from the University of Oklahoma, from which she graduated with the distinction of being the top student in the College of Arts & Sciences. She then pursued her Ph.D. in Bioengineering from Rice University as a National Science Foundation Graduate Research Fellow under the guidance of Jennifer West, where she developed nanoparticle-mediated photothermal therapy. Emily is now a NIH National Research Service Award Postdoctoral Fellow and an International Institute for Nanotechnology Postdoctoral Fellow with Chad Mirkin in the Department of Chemistry at Northwestern University, where she is creating spherical nucleic acids for gene regulation of cancer.