Robust Optimization and Robustness Quantification in Intensity Modulated Proton Therapy
Wei Liu, Assistant Professor, Dept. of Radiation Oncology, Mayo Clinic Arizona
Adjunct Faculty, Dept. of Biomedical Informatics, Arizona State University
Associate Member, Graduate School of Biomedical Sciences, the University of Texas Health Science Center at Houston, Houston, TX
Friday, April 25, 2014
Brickyard (BYENG) 210 [map], Tempe campus
Intensity-Modulated Proton Therapy (IMPT) is highly sensitive to uncertainties in beam range and patient setup. In the worst case and nominal scenarios, robustly optimized plans showed better target coverage, improved dose homogeneity, and lower or equivalent dose to organs at risk (OARs). Robust optimization provided significantly more robust dose distributions to targets and organs than conventional optimization in H&N using IMPT. Reduction of PTV and planning directly based on CTV provided better or equivalent OAR sparing.
Wei Liu earned his Ph.D. from Princeton University in 2007. After working in The University of Texas MD Anderson Cancer Center for three years, Liu joined Department of Radiation Oncology of Mayo Clinic Arizona in July 2013 as an assistant professor. His research was mostly focused on the planning research in radiation therapy, especially in intensity-modulated proton therapy. In August 2012, he was awarded the NIH/NCI Career Award for his research in robust optimization in IMPT.